Cambridge University Press requested Woolhouse write a biography of Locke, the last major biography being Maurice Cranston's 1957 work. Woolhouse's biography appeared in 2007.
After his death, York's Department of Philosophy founded the Roger Woolhouse Prize, an annual £500 prize awarded to MA Philosophy students.
- Locke (Prentice Hall / Harvester Wheatsheaf, 1984).
- The Empiricists (Oxford University Press, 1988).
- Descartes, Spinoza, Leibniz: The Concept of Substance in Seventeenth Century Metaphysics (Routledge, 1993).
- Locke: A Biography (Cambridge University Press, 2007).
- Starting with Leibniz (Continuum, 2010).